Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812162 | 0.87 | ACHE (0.68) | ACHEMCOLN3L3MBTL1AKR1C3ALDH1A1 | |
| SCHEMBL19640887 | 0.83 | PSEN1 (0.57) | ACHEAKR1C3ALDH1A1PKMMMP2 | |
| SCHEMBL19640864 | 0.83 | ESR1 (0.60) | ACHEAKR1C3MMP2CA1CA2 | |
| SCHEMBL19640858 | 0.83 | AKR1C3 (0.49) | L3MBTL1AKR1C3KDM4EPKMMMP2 | |
| SCHEMBL19640837 | 0.83 | AKR1C3 (0.49) | ACHEMCOLN3L3MBTL1AKR1C3HSD11B1 | |
| SCHEMBL19640791 | 0.82 | ACHE (0.54) | ACHEL3MBTL1AKR1C3ALDH1A1KDM4E | |
| SCHEMBL21913505 | 0.82 | ACHE (0.54) | ACHEMCOLN3L3MBTL1AKR1C3ALDH1A1 | |
| SCHEMBL19640805 | 0.82 | ALDH1A1 (0.55) | L3MBTL1AKR1C3ALDH1A1KDM4EPKM | |
| SCHEMBL19640890 | 0.81 | AKR1C3 (0.53) | ACHEAKR1C3ALDH1A1MMP2SMN1; SMN2 | |
| SCHEMBL19640886 | 0.79 | AKR1C3 (0.52) | ACHEAKR1C3ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464288-B1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2020-12-23 | — | — | EP | disclosed |
| EP-3464288-B1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2020-12-23 | — | — | EP | disclosed |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-01 | — | — | US | disclosed |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-01 | — | — | US | disclosed |
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2017-11-30 | — | — | US | disclosed |
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | Bayer Pharma AG (DE) | 2017-11-30 | — | — | US | disclosed |
| WO-2017202817-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL] (1H-1,2,3-TRIAZOL-4-YL)METHANONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342082-A1 | [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL)METHANONES | PKD1, PKD2, PDK3 | ACHE 4604/4885MCOLN3 947/4885L3MBTL1 3805/4885 |
| US-10167293-B2 | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones | PKD1, PKD2, PDK3 | ACHE 4604/4885MCOLN3 947/4885L3MBTL1 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.