Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 15/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366113 | 0.88 | GAA (0.42) | RIPK1KLKB1 | |
| SCHEMBL19641457 | 0.78 | RIPK1 (0.42) | RIPK1 | |
| SCHEMBL19658528 | 0.77 | CYP19A1 (0.31) | — | |
| SCHEMBL16971877 | 0.71 | F11 (0.38) | KLKB1DGAT1 | |
| SCHEMBL16972036 | 0.71 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL16972033 | 0.71 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL19457965 | 0.70 | F11 (0.45) | KLKB1 | |
| SCHEMBL16971691 | 0.70 | KLKB1 (0.33) | KLKB1DGAT1 | |
| SCHEMBL16971693 | 0.70 | KLKB1 (0.33) | KLKB1DGAT1 | |
| SCHEMBL18366357 | 0.66 | GAA (0.50) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-B1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |