Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL196427 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27547982 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28537821 | 0.93 | HCAR2 (0.60) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27937602 | 0.87 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL6924578 | 0.86 | HCAR2 (0.60) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2223143 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL11284804 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2223150 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL9261130 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6907426 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9005592-B2 | Compositions having HASE rheology modifiers | RHODIA OPERATIONS (FR) | 2015-04-14 | — | — | US | claimed |
| CN-102099004-B | Oral compositions and uses thereof | COLGATE PALMOLIVE CO | 2014-08-06 | — | — | CN | claimed |
| US-20140099276-A1 | Compositions Having Hase Rheology Modifiers | RHODIA OPERATIONS (FR) | 2014-04-10 | — | — | US | claimed |
| US-8501865-B2 | Compositions having HASE rheology modifiers | RHODIA OPERATIONS (FR) | 2013-08-06 | — | — | US | claimed |
| US-20130129647-A1 | Compositions Having Hase Rheology Modifiers | RHODIA OPERATIONS (FR) | 2013-05-23 | — | — | US | claimed |
| JP-2012500200-A | — | — | 2012-01-05 | — | — | JP | claimed |
| EP-2323614-A2 | ORAL CARE COMPOSITIONS COMPRISING CAPSULES | Colgate-Palmolive Company (US) | 2011-05-25 | — | — | EP | claimed |
| WO-2010019587-A2 | ORAL CARE COMPOSITIONS CONTAINING BEADS | COLGATE-PALMOLIVE COMPANY (US) | 2010-02-18 | — | — | WO | claimed |
| WO-2006019881-A2 | COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS AND BACTERIAL INFECTIONS | ELDRIDGE GARY R (US) | 2006-02-23 | — | — | WO | claimed |
| US-20250206881-A1 | MODIFIED LYSINE-BASED POLYMER AND COMPOSITIONS COMPRISING THE SAME | BASF SE (DE) | 2025-06-26 | — | — | US | disclosed |
| EP-4504820-A1 | MODIFIED LYSINE-BASED POLYMER AND COMPOSITIONS COMPRISING THE SAME | BASF SE (DE) | 2025-02-12 | — | — | EP | disclosed |
| CN-119032120-A | Modified lysine-based polymers and compositions containing the same | 巴斯夫欧洲公司 | 2024-11-26 | — | — | CN | disclosed |
| US-20240216241-A1 | Oral Care Compositions and Methods of Use | COLGATE-PALMOLIVE COMPANY (US) | 2024-07-04 | — | — | US | disclosed |
| EP-4391995-A1 | HERBAL ORAL CARE COMPOSITIONS | Colgate-Palmolive Company (US) | 2024-07-03 | — | — | EP | disclosed |
| CN-1233945-A | Ostomy appliance | COLOPLAST AS (DK) | 1999-11-03 | — | — | CN | disclosed |
| US-5624745-A | Dental adhesive device and method for producing same | COMBE INCORPORATED (US) | 1997-04-29 | — | — | US | disclosed |
| WO-1996039985-A1 | DENTAL ADHESIVE DEVICE AND METHOD OF MAKING | COMBE INCORPORATED (US) | 1996-12-19 | — | — | WO | disclosed |
| US-4632880-A | Dental adhesive device and method of producing same | COMBE INCORPORATED (US) | 1986-12-30 | — | — | US | disclosed |
| US-4503116-A | Dental adhesive device and method of producing same | COMBE INCORPORATED (US) | 1985-03-05 | — | — | US | disclosed |
| US-3876771-A | SKIN PROTECTIVE GEL CONTAINING POLYVINYL METHYLETHER OR MONOISOPROPYL ESTER OF POLYVINYL METHYLETHER MALEIC ACID | HALLISTER INC | 1975-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140099276-A1 | Compositions Having Hase Rheology Modifiers | WEE2, CCNE2, HPSE | TSHR 4655/4885TP53 2407/4885EGLN1 350/4885 |
| US-20130129647-A1 | Compositions Having Hase Rheology Modifiers | WEE2, CCNE2, HPSE | TSHR 4655/4885TP53 2407/4885EGLN1 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.