Lufenuron

Lufenuron

SCHEMBL19643246

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(OC(F)(F)C(F)C(F)(F)F)cc1Cl.O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(OC(F)(F)C(F)F)c(Cl)c1

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.83
KMT2A Q03164 6/20 0.83
MAPT P10636 4/20 0.83
USP2 O75604 1/20 0.83
ALOX15 P16050 1/20 0.83
POLB P06746 2/20 0.42
ATM Q13315 1/20 0.39
RECQL P46063 2/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
GAA P10253 1/20 0.36
THRB P10828 1/20 0.36
TLR7 Q9NYK1 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36
PYGL P06737 1/20 0.35
PKM P14618 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lufenuron SCHEMBL27105 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL29850969 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL29350147 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL4131569 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL15555900 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL28709254 0.91 KMT2A (1.00) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL7586417 0.89 MEN1 (0.68) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL7587434 0.89 KMT2A (0.88) MEN1KMT2AMAPTUSP2ALOX15
Hexaflumuron SCHEMBL26793 0.87 MEN1 (0.59) MEN1KMT2AMAPTUSP2ALOX15
Lufenuron SCHEMBL7198368 0.85 MEN1 (0.77) MEN1KMT2AMAPTUSP2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017205751-A1 IMPROVED INSECT CONTROL STRATEGIES UTILIZING PHEROMONES AND RNAI PROVIVI, INC. (US) 2017-11-30 WO disclosed