Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.88 |
| ▸ | MEN1 | O00255 | 5/20 | 0.88 |
| ▸ | MAPT | P10636 | 3/20 | 0.88 |
| ▸ | USP2 | O75604 | 1/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.88 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lufenuron SCHEMBL27105 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| Lufenuron SCHEMBL29850969 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| Lufenuron SCHEMBL29350147 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| Lufenuron SCHEMBL4131569 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| Lufenuron SCHEMBL15555900 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| Lufenuron SCHEMBL28709254 | 0.94 | KMT2A (1.00) | KMT2AMEN1MAPTUSP2ALOX15 | |
| SCHEMBL7591855 | 0.94 | KMT2A (0.85) | KMT2AMEN1MAPTUSP2ALOX15 | |
| SCHEMBL7585954 | 0.93 | KMT2A (0.83) | KMT2AMEN1MAPTUSP2ALOX15 | |
| SCHEMBL10934594 | 0.93 | KMT2A (0.83) | KMT2AMEN1MAPTUSP2ALOX15 | |
| SCHEMBL28933698 | 0.91 | KMT2A (0.76) | KMT2AMEN1MAPTUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896532-B1 | ACYL UREA COMPOUNDS FOR THE TREATMENT OF COCCIDIOIDOMYCOSIS IN WARM-BLOODED ANIMALS | NOVARTIS AG (CH) | 2002-10-02 | — | — | EP | claimed |
| EP-0896532-A1 | ACYL UREA COMPOUNDS FOR THE TREATMENT OF COCCIDIOIDOMYCOSIS IN WARM-BLOODED ANIMALS | Novartis AG (CH) | 1999-02-17 | — | — | EP | claimed |
| US-5837734-A | Method for the treatment of coccidioidomycosis in warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-11-17 | — | — | US | claimed |
| WO-1997040826-A1 | ACYL UREA COMPOUNDS FOR THE TREATMENT OF COCCIDIOIDOMYCOSIS IN WARM-BLOODED ANIMALS | NOVARTIS AG (CH) | 1997-11-06 | — | — | WO | claimed |
| US-5416102-A | Administering orally, by injection or implantation, a dosage of flea growth inhibiting benzoyl urea compound | CIBA-GEIGY CORPORATION (US) | 1995-05-16 | — | — | US | claimed |
| US-5837734-A | Method for the treatment of coccidioidomycosis in warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-11-17 | — | — | US | disclosed |
| US-5416102-A | Administering orally, by injection or implantation, a dosage of flea growth inhibiting benzoyl urea compound | CIBA-GEIGY CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| US-4518804-A | INTERMEDIATES FOR INSECTICDAL N-AROYL-N'-PHENYL UREAS | THE DOW CHEMICAL COMPANY (US) | 1985-05-21 | — | — | US | disclosed |