Lufenuron

Lufenuron

SCHEMBL4131569

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(OC(F)(F)[C@@H](F)C(F)(F)F)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 1.00
MEN1 O00255 4/20 1.00
MAPT P10636 2/20 1.00
USP2 O75604 1/20 1.00
ALOX15 P16050 1/20 1.00
POLB P06746 1/20 0.49
ATM Q13315 1/20 0.46
RECQL P46063 2/20 0.41
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 2/20 0.39
TLR7 Q9NYK1 1/20 0.38
GAA P10253 2/20 0.38
THRB P10828 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PYGL P06737 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
DHODH Q02127 1/20 0.37
NPC1 O15118 1/20 0.37
MAPK1 P28482 1/20 0.37
IL2 P60568 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lufenuron SCHEMBL29850969 1.00 KMT2A (1.00) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL15555900 1.00 KMT2A (1.00) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL27105 1.00 KMT2A (1.00) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL28709254 1.00 KMT2A (1.00) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL29350147 1.00 KMT2A (1.00) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL7587434 0.94 KMT2A (0.88) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL9990506 0.93 KMT2A (0.87) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL7591855 0.92 KMT2A (0.85) KMT2AMEN1MAPTUSP2ALOX15
Lufenuron SCHEMBL19643246 0.91 MEN1 (0.83) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL7585954 0.91 KMT2A (0.83) KMT2AMEN1MAPTUSP2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8263099-B2 Insect growth regulating composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-09-11 US disclosed
US-20090246239-A1 INSECT GROWTH REGULATING COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-10-01 US disclosed
US-20090081307-A1 Pesticidal composition SUMITOMO CHEMICAL COMPANY, LIMITED 2009-03-26 US disclosed
US-20050202057-A1 Insect growth regulating composition SUMITOMO CHEMICAL COMPANY, LIMITED 2005-09-15 US disclosed
US-6884755-B2 Pesticidal composition SYNGENTA CROP PROTECTION, INC. (US) 2005-04-26 US disclosed
US-20030166618-A1 Pesticidal composition SENN ROBERT (CH) 2003-09-04 US disclosed
EP-0915656-B1 PESTICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2003-07-23 EP disclosed
US-6514954-B1 For controlling insects or representatives of the order Acarina SYNGENTA CROP PROTECTION, INC. 2003-02-04 US disclosed
US-6500416-B2 FLUID FLOW; INSECTICIDE; MITICIDE SYNGENTA CROP PROTECTION, INC. 2002-12-31 US disclosed
US-20010021378-A1 Pesticide SYNGENTA CROP PROTECTION, INC. 2001-09-13 US disclosed
WO-1999025187-A2 PESTICIDAL COMPOSITIONS OF EMAMECTIN NOVARTIS AG (CH) 1999-05-27 WO disclosed
EP-0909130-A1 PESTICIDE Novartis AG (CH) 1999-04-21 EP disclosed
WO-1997042815-A1 PESTICIDE NOVARTIS AG (CH) 1997-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166618-A1 Pesticidal composition TUBA3C, DDT, TUBB3 KMT2A 2096/4885MEN1 2214/4885MAPT 2830/4885
US-20010021378-A1 Pesticide DDT, KISS1R, ACHE KMT2A 1919/4885MEN1 1098/4885MAPT 1014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.