Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18940403 | 0.84 | RIPK1 (0.37) | P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18940440 | 0.84 | TAS2R8 (0.38) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL20331205 | 0.83 | TAS2R8 (0.40) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18961333 | 0.82 | MAPK7 (0.35) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18940435 | 0.82 | TAS2R8 (0.36) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18961351 | 0.82 | RIPK1 (0.34) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18961394 | 0.82 | TAS2R8 (0.37) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18961397 | 0.79 | TAS2R8 (0.39) | TAS2R8P2RY14RIPK1CDK5CDK5R1 | |
| SCHEMBL18961316 | 0.78 | KMT2A (0.45) | RIPK1CDK5CDK5R1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18961340 | 0.78 | TAS2R8 (0.35) | TAS2R8P2RY14RIPK1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828362-B2 | 1,4-disubstituted imidazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-11-28 | — | — | US | disclosed |
| US-9828362-B2 | 1,4-disubstituted imidazole derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-11-28 | — | — | US | disclosed |