Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17031808 | 0.87 | MEN1 (0.43) | CNR2MEN1KMT2ACTSATP53 | |
| SCHEMBL20307119 | 0.83 | ADORA3 (0.49) | MEN1KMT2ATP53MAPTHPGD | |
| SCHEMBL17034442 | 0.79 | ABL1 (0.42) | CNR2MEN1KMT2ACTSATP53 | |
| SCHEMBL17033050 | 0.77 | HSP90AA1 (0.43) | CNR2MEN1KMT2ATP53MAPT | |
| SCHEMBL19091563 | 0.74 | LTB4R (0.40) | CNR2MEN1KMT2ATP53MAPT | |
| SCHEMBL18307709 | 0.72 | ALDH1A1 (0.43) | MEN1KMT2ATP53MAPTKDM4C | |
| SCHEMBL17031818 | 0.71 | ADORA2A (0.51) | MEN1KMT2AMAPTKDM5BHPGD | |
| SCHEMBL17031828 | 0.69 | ADORA3 (0.53) | MEN1KMT2AMAPTHPGDHSP90AA1 | |
| SCHEMBL17031830 | 0.68 | PSD (0.40) | MEN1KMT2ACTSAMAPTHPGD | |
| SCHEMBL24359978 | 0.66 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828396-B2 | Alkyne compounds for treatment of complement mediated disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |