Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 2/20 | 0.32 |
| ▸ | ATP4B | P51164 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858647 | 1.00 | PLA2G4A (0.36) | PLA2G4ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL23583870 | 0.98 | PLA2G4A (0.37) | PLA2G4ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL21720343 | 0.92 | ALDH1A1 (0.33) | PLA2G4ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL23788958 | 0.83 | TSHR (0.41) | PLA2G4ASMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL21884277 | 0.81 | ALDH1A1 (0.35) | PLA2G4ASMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL21884187 | 0.80 | ALDH1A1 (0.32) | PLA2G4AALDH1A1CNR2CNR1 | |
| SCHEMBL20927061 | 0.79 | PLA2G4A (0.31) | PLA2G4A | |
| SCHEMBL18737542 | 0.79 | PLA2G4A (0.31) | PLA2G4A | |
| SCHEMBL24486553 | 0.77 | PLA2G4A (0.31) | PLA2G4A | |
| SCHEMBL21720602 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828377-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |