Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27293915 | 0.84 | MAPT (0.56) | NPC1POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL9097509 | 0.80 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL29492473 | 0.80 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL203373 | 0.80 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL9282073 | 0.80 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL125621 | 0.80 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL29363032 | 0.80 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL27983454 | 0.80 | PRKCI (0.48) | NPC1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29492479 | 0.78 | PBRM1 (0.83) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL9101086 | 0.78 | PBRM1 (0.83) | PBRM1NPC1MITFLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755657-B1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA INC (US) | 2017-11-29 | — | — | EP | disclosed |