Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970416 | 0.83 | NPC1 (0.63) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1251440 | 0.79 | KMT2A (0.65) | LMNAALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL4251092 | 0.78 | MAPT (0.70) | LMNAALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL16318478 | 0.76 | MAPT (0.67) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL16604283 | 0.76 | NPC1 (0.76) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8758479 | 0.75 | LMNA (0.66) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL13085941 | 0.75 | LMNA (0.66) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1520310 | 0.75 | NPC1 (0.65) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1249138 | 0.74 | KMT2A (0.63) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL8555112 | 0.74 | NPC1 (0.72) | ALDH1A1KMT2AMEN1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |