Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.63 |
| ▸ | RAB9A | P51151 | 10/20 | 0.63 |
| ▸ | PKM | P14618 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965130 | 0.83 | LMNA (0.75) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL16604283 | 0.83 | NPC1 (0.76) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL1520310 | 0.82 | NPC1 (0.65) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL17675306 | 0.81 | NPC1 (0.72) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL8555112 | 0.81 | NPC1 (0.72) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL1972210 | 0.80 | ALOX15 (0.52) | HSD17B10 | |
| SCHEMBL2946989 | 0.79 | NPC1 (0.71) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL16594545 | 0.79 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL21349103 | 0.79 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL26293792 | 0.79 | NPC1 (0.70) | NPC1RAB9APKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |