Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658659 | 0.85 | CKS1B (0.49) | CKS1BSKP1SKP2RIPK1KDM1A | |
| SCHEMBL19652097 | 0.85 | MEN1 (0.55) | CKS1BSKP1SKP2SSTR4ALDH1A1 | |
| SCHEMBL20064248 | 0.83 | CKS1B (0.54) | CKS1BSKP1SKP2SSTR4KMT2A | |
| SCHEMBL19652156 | 0.83 | SSTR4 (0.49) | CKS1BSKP1SKP2SSTR4ALDH1A1 | |
| SCHEMBL19652283 | 0.81 | CYP11B2 (0.45) | RIPK1KDM1AMEN1KMT2ACYP11B2 | |
| SCHEMBL31038865 | 0.76 | PDE10A (0.50) | CKS1BSKP1SKP2 | |
| SCHEMBL19652155 | 0.75 | ADRB1 (0.51) | CKS1BSKP1SKP2ALDH1A1GAA | |
| SCHEMBL19652148 | 0.75 | KDM4E (0.59) | CKS1BSKP1SKP2ALDH1A1GAA | |
| SCHEMBL20152891 | 0.74 | RIPK1 (0.53) | NPSR1RIPK1 | |
| SCHEMBL18255044 | 0.73 | KDM4E (0.57) | ALDH1A1LMNARIPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CKS1B 239/4885SKP1 2240/4885SKP2 2256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.