Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.53 |
| ▸ | ULK1 | O75385 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17547477 | 0.87 | PTK2B (0.71) | IGF1RPTK2BULK1 | |
| SCHEMBL19654311 | 0.85 | PTK2B (0.68) | PTK2BULK1SYK | |
| SCHEMBL19654266 | 0.84 | ULK1 (0.61) | PTK2BULK1SYK | |
| SCHEMBL19654312 | 0.83 | ULK1 (0.72) | PTK2BULK1SYK | |
| SCHEMBL15256327 | 0.83 | IGF1R (0.79) | IGF1RNTRK1 | |
| SCHEMBL19654321 | 0.83 | ULK1 (0.67) | PTK2BULK1SYK | |
| SCHEMBL19654320 | 0.81 | ULK1 (0.75) | PTK2BULK1SYK | |
| SCHEMBL19654185 | 0.81 | ULK1 (0.64) | PTK2BULK1SYK | |
| SCHEMBL19654270 | 0.81 | ULK1 (0.57) | PTK2BULK1SYK | |
| SCHEMBL19654271 | 0.80 | ULK1 (0.57) | PTK2BULK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342088-A1 | NOVEL ULK1 INHIBITORS AND METHODS USING SAME | ULK1, ULK2, ULK3 | IGF1R 1164/4885PTK2B 813/4885ULK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.