Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.48 |
| ▸ | TAF1 | P21675 | 1/20 | 0.48 |
| ▸ | TAF11 | Q15544 | 1/20 | 0.48 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19651863 | 0.84 | HSP90AA1 (0.54) | HPGDCECR2BRD4BRD9TAF1 | |
| SCHEMBL19657105 | 0.80 | CECR2 (0.47) | HPGDCECR2BRD4BRD9TAF1 | |
| SCHEMBL15262556 | 0.76 | HPGD (0.59) | HPGDALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL19657110 | 0.74 | ACACB (0.53) | HPGDCECR2BRD4BRD9TAF1 | |
| SCHEMBL19651854 | 0.74 | HSP90AA1 (0.46) | CECR2BRD4BRD9TAF1TAF11 | |
| SCHEMBL15263012 | 0.73 | HPGD (0.59) | HPGDBRD4ALDH1A1KDM4EGAA | |
| SCHEMBL8050723 | 0.73 | HPGD (0.59) | HPGDBRD4ALDH1A1KDM4EGAA | |
| SCHEMBL24975811 | 0.73 | HPGD (0.52) | HPGDALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL15262953 | 0.71 | ALDH1A1 (0.69) | HPGDALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL22353354 | 0.71 | HPGD (0.56) | HPGDBRD4ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | disclosed |
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRPF3 | HPGD 1603/4885CECR2 246/4885BRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.