Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.54 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657383 | 0.85 | CREBBP (0.45) | CREBBPSMYD2PLA2G7BRD4RIPK1 | |
| SCHEMBL19657916 | 0.85 | CREBBP (0.45) | CREBBPSMYD2PLA2G7BRD4RIPK1 | |
| SCHEMBL19657776 | 0.84 | CREBBP (0.44) | CREBBPSMYD2PLA2G7BRD4GRIN2B | |
| SCHEMBL19657381 | 0.84 | CREBBP (0.56) | CREBBPSMYD2PLA2G7BRD4 | |
| SCHEMBL24258501 | 0.83 | CREBBP (0.53) | CREBBPSMYD2 | |
| SCHEMBL19657755 | 0.73 | CREBBP (0.78) | CREBBPSMYD2BRD4 | |
| SCHEMBL19657522 | 0.70 | CREBBP (1.00) | CREBBP | |
| SCHEMBL19657828 | 0.70 | CREBBP (0.36) | CREBBPSMYD2PLA2G7RIPK1GRIN2B | |
| SCHEMBL19657386 | 0.70 | CREBBP (0.36) | CREBBPSMYD2PLA2G7RIPK1GRIN2B | |
| SCHEMBL24258514 | 0.68 | CREBBP (0.36) | CREBBPPLA2G7RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |