Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657916 | 0.85 | CREBBP (0.45) | CREBBPABCB1SMYD2TAS1R3TAS1R1 | |
| SCHEMBL19657383 | 0.85 | CREBBP (0.45) | CREBBPABCB1GAASMYD2 | |
| SCHEMBL19657776 | 0.84 | CREBBP (0.44) | CREBBPABCB1SMYD2MEN1KMT2A | |
| SCHEMBL19657381 | 0.84 | CREBBP (0.56) | CREBBPABCB1SMYD2 | |
| SCHEMBL19657387 | 0.83 | CREBBP (0.54) | CREBBPSMYD2 | |
| SCHEMBL19657755 | 0.73 | CREBBP (0.78) | CREBBPABCB1SMYD2MEN1KMT2A | |
| SCHEMBL24258514 | 0.70 | CREBBP (0.36) | CREBBPABCB1GAAMEN1KMT2A | |
| SCHEMBL19644381 | 0.69 | CREBBP (1.00) | CREBBP | |
| SCHEMBL19657828 | 0.68 | CREBBP (0.36) | CREBBPABCB1GAASMYD2 | |
| SCHEMBL19657386 | 0.68 | CREBBP (0.36) | CREBBPABCB1SMYD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |