Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657828 | 0.84 | CREBBP (0.36) | CREBBPRIPK1PLA2G7ABCB1FTO | |
| SCHEMBL19657383 | 0.82 | CREBBP (0.45) | CREBBPRIPK1PLA2G7ABCB1FTO | |
| SCHEMBL19657386 | 0.71 | CREBBP (0.36) | CREBBPRIPK1PLA2G7ABCB1CDK4 | |
| SCHEMBL24258501 | 0.70 | CREBBP (0.53) | CREBBPMEN1KMT2AABCB1GAA | |
| SCHEMBL19644450 | 0.70 | CREBBP (0.55) | CREBBPUCHL1RIPK1MEN1KMT2A | |
| SCHEMBL19657916 | 0.69 | CREBBP (0.45) | CREBBPRIPK1PLA2G7ABCB1CDK4 | |
| SCHEMBL19657381 | 0.69 | CREBBP (0.56) | CREBBPPLA2G7ABCB1CDK4CCND1 | |
| SCHEMBL19657776 | 0.69 | CREBBP (0.44) | CREBBPMEN1KMT2APLA2G7ABCB1 | |
| SCHEMBL19657387 | 0.68 | CREBBP (0.54) | CREBBPRIPK1PLA2G7 | |
| SCHEMBL19657912 | 0.67 | CREBBP (0.41) | CREBBPRIPK1PLA2G7ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |