Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657386 | 0.88 | CREBBP (0.36) | CREBBPRIPK1PLA2G7KCNQ2GRIN2B | |
| SCHEMBL19657912 | 0.84 | CREBBP (0.41) | CREBBPRIPK1PLA2G7KCNQ2SMYD2 | |
| SCHEMBL24258514 | 0.84 | CREBBP (0.36) | CREBBPRIPK1PLA2G7FTOABCB1 | |
| SCHEMBL19657383 | 0.82 | CREBBP (0.45) | CREBBPRIPK1PLA2G7FTOGRIN2B | |
| SCHEMBL24258482 | 0.72 | RIPK1 (0.45) | CREBBPRIPK1PLA2G7KCNQ2GRIN2B | |
| SCHEMBL19657387 | 0.70 | CREBBP (0.54) | CREBBPRIPK1PLA2G7GRIN2BSMYD2 | |
| SCHEMBL19657916 | 0.69 | CREBBP (0.45) | CREBBPRIPK1PLA2G7GRIN2BSMYD2 | |
| SCHEMBL24258523 | 0.69 | GPR142 (0.35) | CREBBPRIPK1 | |
| SCHEMBL19657776 | 0.69 | CREBBP (0.44) | CREBBPPLA2G7GRIN2BSMYD2ABCB1 | |
| SCHEMBL19657381 | 0.69 | CREBBP (0.56) | CREBBPPLA2G7SMYD2ABCB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |