Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | S100B | P04271 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657848 | 0.87 | ATAD2 (0.57) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19657568 | 0.85 | ATAD2 (0.41) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL12136691 | 0.76 | RAB9A (0.57) | HSD17B10ALDH1A1SMN1; SMN2BRD4BRPF1 | |
| SCHEMBL9027061 | 0.74 | ATAD2 (0.44) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19657572 | 0.74 | ADORA2B (0.41) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19657844 | 0.74 | RAB9A (0.39) | ATAD2HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19657546 | 0.74 | ATAD2 (0.71) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19657534 | 0.73 | HSD17B10 (0.43) | ATAD2S100BHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19657853 | 0.73 | ATAD2 (0.35) | ATAD2S100BHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL25752333 | 0.73 | ATM (0.40) | HSD17B10ALDH1A1KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |