Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025772 | 0.79 | KMT2A (0.48) | RAB9ASMN1; SMN2GBA1NPC1MEN1 | |
| SCHEMBL25023335 | 0.79 | RAB9A (0.53) | RAB9ASMN1; SMN2ALDH1A1RECQLGBA1 | |
| SCHEMBL13403442 | 0.79 | XIAP (0.61) | RAB9ASMN1; SMN2ALDH1A1RECQLGBA1 | |
| SCHEMBL12890512 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2ALDH1A1RECQLGBA1 | |
| SCHEMBL22822777 | 0.76 | RAB9A (0.50) | RAB9ASMN1; SMN2ALDH1A1RECQLGBA1 | |
| SCHEMBL11279908 | 0.74 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL4717737 | 0.74 | RAB9A (0.64) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL23967015 | 0.70 | BRD4 (0.54) | RAB9ASMN1; SMN2ALDH1A1RECQLNPC1 | |
| SCHEMBL2483314 | 0.70 | KMT2A (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL19657645 | 0.70 | FBP1 (0.48) | RAB9ASMN1; SMN2GBA1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |