Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 3/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.48 |
| ▸ | GCK | P35557 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657672 | 0.83 | FBP1 (0.49) | FBP1CREBBPGCKADORA3FGFR1 | |
| SCHEMBL2089387 | 0.81 | FBP1 (0.52) | FBP1CREBBPGCKADORA3FGFR1 | |
| SCHEMBL21024032 | 0.79 | ALDH1A1 (0.46) | FBP1CREBBPGCKADORA3FGFR1 | |
| SCHEMBL19657958 | 0.79 | FBP1 (0.47) | FBP1CREBBPGCKADORA3FGFR1 | |
| SCHEMBL14350863 | 0.71 | KMT2A (0.59) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19657675 | 0.70 | RAB9A (0.53) | GCKNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2088650 | 0.70 | FBP1 (0.61) | FBP1CREBBPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2087609 | 0.70 | FBP1 (0.61) | FBP1CREBBPNPC1RAB9AMEN1 | |
| SCHEMBL31492254 | 0.69 | NR3C2 (0.49) | ADORA3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2087732 | 0.69 | FBP1 (0.56) | FBP1CREBBPMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |