Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14266179 | 0.84 | ALDH1A1 (0.59) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL5421354 | 0.82 | APP (0.49) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL21237208 | 0.80 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL28357340 | 0.79 | ALDH1A1 (0.58) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL2950955 | 0.79 | DHODH (0.72) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL2959887 | 0.77 | HTR3A (0.58) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL29728167 | 0.77 | KDM4E (0.62) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL20361419 | 0.76 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL1199992 | 0.75 | PTPN2 (0.68) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL29633759 | 0.73 | ALDH1A1 (1.00) | NPC1RAB9AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |