Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302209 | 0.85 | CNR2 (0.51) | KCNA5KCNH2CNR2HTR1AHTR2A | |
| SCHEMBL1976194 | 0.81 | CNR2 (0.39) | CNR2HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL302217 | 0.80 | HTR2C (0.47) | KCNA5KCNH2HTR1AHTR2AHTR2C | |
| SCHEMBL303069 | 0.78 | HTR2C (0.55) | CNR2HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL306481 | 0.77 | PARP1 (0.42) | CNR2LMNAHPGDTSHRHTT | |
| SCHEMBL1976235 | 0.77 | CNR2 (0.44) | CNR2HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL315878 | 0.75 | NTRK1 (0.33) | CNR2LMNAHPGDTSHRNPC1 | |
| SCHEMBL3230248 | 0.73 | LMNA (0.57) | LMNAHPGDTSHRNPC1RAB9A | |
| SCHEMBL3260086 | 0.71 | TSHR (0.39) | CNR2HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL1964857 | 0.71 | HDAC4 (0.54) | HPGDNPC1RAB9AHTTHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |