Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 10/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18510350 | 0.89 | CDK1 (0.71) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL21137281 | 0.86 | CDK1 (0.57) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL19661692 | 0.83 | ADORA2A (0.64) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL22326729 | 0.79 | ADORA2A (0.66) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL18521194 | 0.79 | CCNB2 (0.82) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL18520056 | 0.79 | YTHDC1 (0.61) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL21316709 | 0.78 | CDK1 (0.81) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL22946798 | 0.77 | ADORA2A (0.68) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL21539482 | 0.77 | CCNB2 (0.66) | CDK1CCNB1CCNB2CCNB3ADORA2A | |
| SCHEMBL18520987 | 0.76 | HTT (0.58) | CDK1CCNB1CCNB2CCNB3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200113924-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113924-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | STING1, CGAS, MAVS | CDK1 1503/4885CCNB1 3518/4885CCNB2 3381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.