Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 6/20 | 0.41 |
| ▸ | CDK8 | P49336 | 6/20 | 0.41 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662999 | 0.88 | CREBBP (0.55) | CREBBPPDE10ACCNCCDK8CYP46A1 | |
| SCHEMBL21237392 | 0.85 | CREBBP (0.51) | CREBBPPDE10ACCNCCDK8CYP46A1 | |
| SCHEMBL21237580 | 0.85 | CREBBP (0.53) | CREBBPPDE10ACCNCCDK8CYP46A1 | |
| SCHEMBL23762133 | 0.76 | CREBBP (0.45) | CREBBPNOTUM | |
| SCHEMBL21237331 | 0.74 | CREBBP (0.40) | CREBBPNOTUMDGAT2 | |
| SCHEMBL23761964 | 0.73 | CREBBP (0.42) | CREBBPNOTUM | |
| SCHEMBL19663332 | 0.73 | CREBBP (0.55) | CREBBPPDE10ACYP46A1NOTUM | |
| SCHEMBL23762061 | 0.72 | HTR3A (0.45) | CREBBP | |
| SCHEMBL23761963 | 0.71 | HTR3A (0.64) | — | |
| SCHEMBL19662985 | 0.71 | CREBBP (0.40) | CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |