Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.69 |
| ▸ | HPGD | P15428 | 9/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | THRB | P10828 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.67 |
| ▸ | CASP3 | P42574 | 2/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244672 | 0.89 | CASP3 (0.80) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2240275 | 0.87 | ALDH1A1 (0.69) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2245659 | 0.87 | ALDH1A1 (0.87) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2245254 | 0.86 | ALDH1A1 (0.68) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2247278 | 0.85 | ALDH1A1 (0.80) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2245522 | 0.84 | ALDH1A1 (0.68) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2245490 | 0.83 | TP53 (0.69) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL16217101 | 0.83 | PTGS2 (0.78) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL10016431 | 0.83 | TP53 (1.00) | TP53POLBRXFP1ALDH1A1HSD17B10 | |
| SCHEMBL2244567 | 0.82 | ALDH1A1 (1.00) | TP53POLBRXFP1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3251694-A1 | DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | Summit (Oxford) Limited (GB) | 2017-12-06 | — | — | EP | disclosed |