Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.44 |
| ▸ | KDM5C | P41229 | 5/20 | 0.43 |
| ▸ | KDM4A | O75164 | 3/20 | 0.43 |
| ▸ | KDM5A | P29375 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 2/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291524 | 1.00 | KDM5B (0.44) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL19574371 | 0.81 | KDM5B (0.45) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL17144518 | 0.77 | TRPV3 (0.50) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL17144520 | 0.77 | TRPV3 (0.50) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL17144516 | 0.74 | ALDH1A1 (0.39) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL19741664 | 0.73 | KDM5A (0.39) | KDM5BKDM5APSMB5KDM4ESIRT2 | |
| SCHEMBL19741660 | 0.73 | KDM5A (0.39) | KDM5BKDM5APSMB5KDM4ESIRT2 | |
| SCHEMBL17144521 | 0.72 | KDM5B (0.45) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL19549130 | 0.72 | KDM5B (0.47) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL19741721 | 0.71 | SMN1; SMN2 (0.42) | KDM5BKDM5CKDM4APSMB5KDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| CN-107434803-A | Histone demethylase inhibitor | 吉利德科学公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-104981458-B | Inhibitors of histone demethylases | 吉利德科学公司 | 2017-07-21 | — | — | CN | disclosed |