Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636702 | 0.85 | KDM5B (0.46) | KDM1ADRD3PDE3BPDE3ADRD2 | |
| SCHEMBL19676424 | 0.82 | KDM5B (0.43) | KDM1ADRD3PDE3BPDE3A | |
| SCHEMBL15994417 | 0.70 | KDM4E (0.43) | KDM1A | |
| SCHEMBL17364569 | 0.68 | KDM4E (0.42) | KDM1A | |
| SCHEMBL16293797 | 0.67 | KDM4E (0.64) | KDM1APOLB | |
| SCHEMBL15636442 | 0.66 | KDM5B (0.52) | — | |
| SCHEMBL15636980 | 0.65 | KDM5B (0.59) | — | |
| SCHEMBL15995309 | 0.64 | KDM4E (0.40) | KDM1A | |
| SCHEMBL16303320 | 0.64 | KDM4E (0.40) | KDM1A | |
| SCHEMBL12395531 | 0.63 | DRD3 (0.61) | DRD3PDE3BPDE3AHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |