Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29025473 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1HTT | |
| SCHEMBL30433202 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1HTT | |
| SCHEMBL16592103 | 0.84 | CYP1A2 (0.52) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1HTT | |
| SCHEMBL13197550 | 0.84 | CYP1A2 (0.52) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL16592086 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL22809511 | 0.83 | CYP1A2 (0.51) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1HTT | |
| SCHEMBL17055786 | 0.82 | AGBL2 (0.46) | ALDH1A1HTTGAACYP1A2CYP3A4 | |
| SCHEMBL15670321 | 0.82 | PTGS2 (0.42) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1HTT | |
| SCHEMBL18600965 | 0.81 | APP (0.50) | SMN1; SMN2RAB9AALDH1A1HTTGAA | |
| SCHEMBL22809449 | 0.80 | SCN9A (0.50) | SMN1; SMN2RAB9AMRGPRX4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914597-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2017-12-06 | — | — | EP | disclosed |