Sugi Predict

Sugi Predict / Compounds / SCHEMBL1966476

SCHEMBL1966476

SCHEMBL1966476

O=C(O)c1cc2nc(Nc3c(Cl)cc(F)cc3Cl)[nH]c2cc1OCCF

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PTGES O14684 6/20 0.36
▸ POLB P06746 1/20 0.35
▸ KDM4C Q9H3R0 1/20 0.35
▸ ABL1 P00519 1/20 0.34
▸ HDAC11 Q96DB2 1/20 0.34
▸ RHEB Q15382 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ PRKAG1 P54619 3/20 0.33
▸ PRKAA2 P54646 3/20 0.33
▸ PRKAA1 Q13131 3/20 0.33
▸ PRKAB1 Q9Y478 3/20 0.33
▸ PRKAB2 O43741 2/20 0.33
▸ PRKAG3 Q9UGI9 2/20 0.33
▸ PRKAG2 Q9UGJ0 2/20 0.33
▸ DDX3X O00571 1/20 0.33
▸ F9 P00740 1/20 0.33
▸ CSNK1E P49674 1/20 0.33
▸ SYK P43405 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1965840 0.87 PTGES (0.37) PTGESPOLBKDM4CCSNK1E
SCHEMBL13393499 0.86 PTGES (0.52) PTGESHDAC11
SCHEMBL16352223 0.83 PTGES (0.46) PTGES
SCHEMBL1973967 0.82 PTGES (0.38) PTGESHDAC11
SCHEMBL16318664 0.81 PTGES (0.54) PTGES
SCHEMBL16318666 0.81 PTGES (0.54) PTGES
SCHEMBL1974351 0.79 PTGES (0.39) PTGESABL1HDAC11PRKAG1PRKAA2
SCHEMBL1973420 0.78 KDR (0.39) PTGESSYK
SCHEMBL3702752 0.77 PTGES (0.53) PTGESHDAC11
SCHEMBL1971110 0.77 PTGES (0.40) PTGESPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150011513-A1 ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2015-01-08 — — US disclosed
US-8916599-B2 1H-benz imidazole-5-carboxamides as anti-inflammatory agents OREXO AB (SE) 2014-12-23 — — US disclosed
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-12-22 — — US disclosed
EP-2334652-A1 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS Boehringer Ingelheim International GmbH (DE) 2011-06-22 — — EP disclosed
WO-2010034796-A1 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents MAPRE2, MAPRE1, H1-4 PTGES 118/4885POLB 3740/4885KDM4C 644/4885
US-20150011513-A1 ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS ABCG2, ABCB1, ABCC1 PTGES 3823/4885POLB 2321/4885KDM4C 3312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.