Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.39 |
| ▸ | F11 | P03951 | 9/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17221294 | 0.95 | KMT2A (0.48) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL29407395 | 0.95 | KMT2A (0.48) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL29405518 | 0.88 | ALDH1A1 (0.51) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL21145582 | 0.88 | ALDH1A1 (0.51) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL19668374 | 0.81 | KCNN4 (0.37) | ALDH1A1 | |
| SCHEMBL30665150 | 0.77 | ALDH1A1 (0.52) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL29697621 | 0.77 | ALDH1A1 (0.55) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL17221299 | 0.77 | ALDH1A1 (0.55) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL17232505 | 0.77 | ALDH1A1 (0.52) | KMT2AALDH1A1TSHRKLKB1F11 | |
| SCHEMBL17221253 | 0.76 | ALDH1A1 (0.51) | KMT2AALDH1A1TSHRKLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464271-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017207983-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-12-07 | — | — | WO | disclosed |