Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 13/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668371 | 0.81 | KMT2A (0.44) | ALDH1A1 | |
| SCHEMBL29407395 | 0.75 | KMT2A (0.48) | ALDH1A1 | |
| SCHEMBL17221294 | 0.75 | KMT2A (0.48) | ALDH1A1 | |
| SCHEMBL22993405 | 0.68 | KLKB1 (0.43) | — | |
| SCHEMBL29390133 | 0.68 | KLKB1 (0.43) | — | |
| SCHEMBL29405518 | 0.66 | ALDH1A1 (0.51) | ALDH1A1 | |
| SCHEMBL21145582 | 0.66 | ALDH1A1 (0.51) | ALDH1A1 | |
| SCHEMBL23088134 | 0.66 | AR (0.32) | ALDH1A1 | |
| SCHEMBL29792775 | 0.66 | AR (0.32) | ALDH1A1 | |
| SCHEMBL22993198 | 0.64 | F11 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464271-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017207983-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-12-07 | — | — | WO | disclosed |