Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233129 | 0.79 | CYP1A2 (0.41) | CYP1A2SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL16429508 | 0.79 | TAAR1 (0.49) | TAAR1CHRNB2CHRNA4CHRNA7CYP1A2 | |
| SCHEMBL28177767 | 0.77 | CYP1A2 (0.37) | CHRNB2CHRNA4CHRNA7CYP1A2SMN1; SMN2 | |
| SCHEMBL28748650 | 0.75 | CHRNB2 (0.50) | TAAR1CHRNB2CHRNA4CHRNA7CYP1A2 | |
| SCHEMBL8918069 | 0.74 | CYP2D6 (0.52) | TAAR1CHRNB2CHRNA4CHRNA7CYP1A2 | |
| SCHEMBL28695999 | 0.74 | HDAC4 (0.43) | CYP1A2SMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL3703819 | 0.73 | MEN1 (0.55) | CYP1A2SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL29590357 | 0.73 | MEN1 (0.55) | CYP1A2SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL20342557 | 0.73 | HDAC4 (0.48) | CYP1A2SMN1; SMN2POLBKDM4ENPC1 | |
| SCHEMBL20707 | 0.73 | CHRNB2 (0.50) | TAAR1CHRNB2CHRNA4CHRNA7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190308987-A1 | DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-10-10 | — | — | US | disclosed |
| EP-3463361-A1 | DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS | Virginia Commonwealth University (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017210105-A1 | DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308987-A1 | DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS | OPRK1, OPRM1, OPRL1 | TAAR1 39/4885CHRNB2 287/4885CHRNA4 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.