Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.71 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | MEN1 | O00255 | 9/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | NPC1 | O15118 | 9/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | STAT1 | P42224 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22521022 | 0.88 | MAPT (0.55) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22520838 | 0.85 | RAB9A (0.71) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22520813 | 0.83 | MAPT (0.67) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22520981 | 0.83 | RAB9A (0.71) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22521012 | 0.77 | CHEK1 (0.46) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22521038 | 0.75 | MEN1 (0.52) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22520816 | 0.75 | MAPT (0.44) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL22520952 | 0.74 | MEN1 (0.61) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL16934937 | 0.73 | KMT2A (0.85) | RAB9AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL10407273 | 0.73 | KDM4E (0.41) | RAB9AMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | NYSNOBIO IRELAND DAC (IE) | 2021-06-03 | — | — | US | disclosed |
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | NYSNOBIO IRELAND DAC (IE) | 2021-06-03 | — | — | US | disclosed |
| US-20200317674-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | An2H Discovery Limited (IE) | 2020-10-08 | — | — | US | disclosed |
| US-20200317674-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | An2H Discovery Limited (IE) | 2020-10-08 | — | — | US | disclosed |
| WO-2017210678-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | An2H Discovery Limited (IE) | 2017-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317674-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | PINK1, ADRM1, LRRK2 | RAB9A 1673/4885MAPT 2001/4885MEN1 4725/4885 |
| US-20210163489-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME | PINK1, ADRM1, LRRK2 | RAB9A 1673/4885MAPT 2001/4885MEN1 4725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.