Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238429 | 0.66 | NOS1 (0.36) | EPHX2 | |
| SCHEMBL21794793 | 0.64 | TSHR (0.47) | EPHX2 | |
| SCHEMBL14947621 | 0.63 | CCR2 (0.32) | — | |
| SCHEMBL2484238 | 0.62 | LMNA (0.34) | EPHX2 | |
| SCHEMBL17018514 | 0.62 | NOS1 (0.33) | — | |
| SCHEMBL2507212 | 0.60 | HPGD (0.33) | — | |
| SCHEMBL26777143 | 0.55 | NOS1 (0.39) | EPHX2 | |
| SCHEMBL25929689 | 0.54 | NOS1 (0.38) | — | |
| SCHEMBL26766002 | 0.54 | NOS1 (0.38) | EPHX2 | |
| SCHEMBL26777147 | 0.54 | NOS1 (0.38) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834549-B2 | 3,3-disubstituted-(8-aza-bicyclo[3.2.1]OCT-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11 (β)-HSD1 | THE UNIVERSITY OF EDINBURGH (GB) | 2017-12-05 | — | — | US | disclosed |