Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16238195 | 0.90 | KIT (0.39) | TRPV1GSK3BDYRK1AVCPFAAH | |
| SCHEMBL16775748 | 0.84 | GSK3B (0.37) | TRPV1GSK3BDYRK1AVCPFAAH | |
| SCHEMBL19670187 | 0.83 | MTOR (0.36) | TRPV1GSK3BDYRK1AFAAHNTRK1 | |
| SCHEMBL19361197 | 0.82 | FAAH (0.43) | TRPV1VCPFAAHNTRK1MEN1 | |
| SCHEMBL17618605 | 0.82 | GSK3B (0.38) | TRPV1CHRM4GSK3BDYRK1AVCP | |
| SCHEMBL17618388 | 0.82 | VCP (0.43) | TRPV1CHRM4VCPFAAHJAK2 | |
| SCHEMBL19689743 | 0.82 | SCD (0.40) | TRPV1CHRM4GSK3BDYRK1AFAAH | |
| SCHEMBL17618594 | 0.82 | FAAH (0.43) | TRPV1CHRM4GSK3BDYRK1AVCP | |
| SCHEMBL17618510 | 0.82 | PIK3CA (0.41) | TRPV1GSK3BDYRK1AVCPFAAH | |
| SCHEMBL17618566 | 0.82 | TRPV1 (0.40) | TRPV1DYRK1ACYP2C19PIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |