Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669047 | 0.83 | TRPV1 (0.35) | MTORPIK3R1GSK3BDYRK1ATRPV1 | |
| SCHEMBL19670528 | 0.82 | GSK3B (0.40) | MTORPIK3R1RECQLSMN1; SMN2GSK3B | |
| SCHEMBL19670184 | 0.82 | MDM2 (0.39) | MTORGSK3BDYRK1AMAPTFAAH | |
| SCHEMBL19365377 | 0.78 | FGFR4 (0.39) | MTORPIK3R1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL19670006 | 0.77 | KARS1 (0.40) | MTORPIK3R1GSK3BDYRK1ATRPV1 | |
| SCHEMBL19670597 | 0.77 | NPC1 (0.40) | TRPV1PTGS1PTGS2NPC1LMNA | |
| SCHEMBL19365513 | 0.75 | PRMT5 (0.41) | ALDH1A1LMNATSHR | |
| SCHEMBL16776056 | 0.74 | FGFR4 (0.41) | TRPV1FAAHNPC1 | |
| SCHEMBL16238195 | 0.74 | KIT (0.39) | RECQLSMN1; SMN2GSK3BDYRK1ATRPV1 | |
| SCHEMBL19365562 | 0.74 | MTOR (0.41) | MTORPIK3R1GSK3BDYRK1AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |