Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970897 | 0.81 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1NOTUMMAPK1 | |
| SCHEMBL13950835 | 0.76 | TXN (0.64) | MAPTSMN1; SMN2ALDH1A1HTTGAA | |
| SCHEMBL3121156 | 0.76 | MAPT (0.59) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL8330270 | 0.75 | MAPT (0.68) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL11432604 | 0.72 | MAPT (0.55) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL9565995 | 0.68 | CA1 (0.58) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL285074 | 0.68 | CYP11B1 (0.73) | MAPTSMN1; SMN2ALDH1A1NOTUMMEN1 | |
| SCHEMBL2532397 | 0.67 | LMNA (0.78) | MAPTNOTUMMEN1KMT2AHTT | |
| SCHEMBL8973510 | 0.67 | MAPT (1.00) | MAPTSMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL28484940 | 0.67 | CYP3A4 (0.71) | MAPTSMN1; SMN2ALDH1A1NOTUMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334665-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-07-10 | — | — | EP | disclosed |
| US-20130143883-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-8389717-B2 | Modulators for amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20120190682-A1 | MODULATORS FOR AMYLOID BETA | GOETSCHI ERWIN (CH) | 2012-07-26 | — | — | US | disclosed |
| EP-2334665-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-20100093731-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2010-04-15 | — | — | US | disclosed |
| WO-2010040661-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143883-A1 | MODULATORS FOR AMYLOID BETA | APP, APH1B, APOB | MAPT 55/4885SMN1; SMN2 2006/4885ALDH1A1 2052/4885 |
| US-20120190682-A1 | MODULATORS FOR AMYLOID BETA | APP, APH1B, APOB | MAPT 55/4885SMN1; SMN2 2006/4885ALDH1A1 2052/4885 |
| US-20100093731-A1 | MODULATORS FOR AMYLOID BETA | APP, APH1B, APOB | MAPT 55/4885SMN1; SMN2 2006/4885ALDH1A1 2052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.