Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670239 | 0.90 | MAP4K1 (0.41) | MAP4K1ABL1 | |
| SCHEMBL19670417 | 0.87 | MAP4K1 (0.42) | MAP4K1ABL1 | |
| SCHEMBL19669952 | 0.87 | POLB (0.41) | MAP4K1ABL1 | |
| SCHEMBL19365567 | 0.87 | HDAC1 (0.43) | MAP4K1ABL1 | |
| SCHEMBL19670526 | 0.86 | MAP4K1 (0.41) | MAP4K1ABL1 | |
| SCHEMBL19365325 | 0.84 | FAAH (0.36) | — | |
| SCHEMBL19670372 | 0.84 | HDAC1 (0.36) | ABL1 | |
| SCHEMBL19364832 | 0.82 | MAP4K1 (0.37) | MAP4K1ABL1 | |
| SCHEMBL19670519 | 0.81 | MAP4K1 (0.41) | MAP4K1ABL1 | |
| SCHEMBL19670415 | 0.81 | ABL1 (0.46) | MAP4K1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |