Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670470 | 0.88 | MAP4K1 (0.38) | ABL1MAP4K1 | |
| SCHEMBL19669975 | 0.87 | MAP4K1 (0.40) | ABL1MAP4K1 | |
| SCHEMBL19365604 | 0.87 | HDAC1 (0.46) | POLBABL1NAMPTSMN1; SMN2ATM | |
| SCHEMBL19670239 | 0.87 | MAP4K1 (0.41) | ABL1MAP4K1 | |
| SCHEMBL19670417 | 0.86 | MAP4K1 (0.42) | ABL1MAP4K1 | |
| SCHEMBL19669983 | 0.86 | HDAC1 (0.42) | POLBABL1NOTUMNAMPTSMN1; SMN2 | |
| SCHEMBL19670526 | 0.85 | MAP4K1 (0.41) | ABL1MAP4K1 | |
| SCHEMBL19365726 | 0.84 | ATM (0.40) | POLBMAP4K1NOTUMNAMPTSMN1; SMN2 | |
| SCHEMBL19670509 | 0.84 | HDAC1 (0.41) | POLBABL1NAMPTSMN1; SMN2ATM | |
| SCHEMBL19670415 | 0.83 | ABL1 (0.46) | ABL1MAP4K1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |