Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365814 | 0.87 | NPC1 (0.41) | ABL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19670417 | 0.83 | MAP4K1 (0.42) | ABL1MAP4K1 | |
| SCHEMBL19669952 | 0.83 | POLB (0.41) | ABL1SMN1; SMN2ALDH1A1MAP4K1 | |
| SCHEMBL19670378 | 0.83 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL19670636 | 0.83 | RAB9A (0.44) | ABL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19670526 | 0.83 | MAP4K1 (0.41) | ABL1MAP4K1 | |
| SCHEMBL19670239 | 0.83 | MAP4K1 (0.41) | ABL1MAP4K1 | |
| SCHEMBL19365607 | 0.82 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL19365329 | 0.82 | RAB9A (0.39) | ABL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19669975 | 0.81 | MAP4K1 (0.40) | ABL1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |