Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632046 | 0.90 | CYP1A2 (0.43) | HTR2AHTR2CCYP1A2MEN1KMT2A | |
| SCHEMBL19365508 | 0.89 | FGFR4 (0.42) | HTR2AHTR2CCYP1A2MEN1KMT2A | |
| SCHEMBL12959011 | 0.85 | CA2 (0.44) | HTR2AHTR2CCYP1A2MEN1KMT2A | |
| SCHEMBL16776363 | 0.85 | CYP1A2 (0.49) | HTR2AHTR2CCYP1A2MEN1KMT2A | |
| SCHEMBL19670654 | 0.84 | CA2 (0.42) | MEN1KMT2AMAPTFYNTRPV1 | |
| SCHEMBL19365266 | 0.84 | GRIN2B (0.38) | HTR2AHTR2CCYP1A2MAPTFYN | |
| SCHEMBL12654500 | 0.84 | CA2 (0.44) | HTR2AHTR2CCYP1A2TRPV1CA2 | |
| SCHEMBL17655481 | 0.84 | KMO (0.43) | HTR2AHTR2CCYP1A2MEN1KMT2A | |
| SCHEMBL19365537 | 0.84 | CA2 (0.43) | HTR2AHTR2CMAPTALDH1A1TRPV1 | |
| SCHEMBL20632114 | 0.83 | FYN (0.39) | HTR2AHTR2CCYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |