Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | PLAT | P00750 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365537 | 0.89 | CA2 (0.43) | CA2CA9PLGPLAUPLAT | |
| SCHEMBL20632673 | 0.86 | CA2 (0.36) | CA2CA9PLGPLAUPLAT | |
| SCHEMBL16776453 | 0.85 | CA2 (0.38) | CA2CA9PLGPLAUPLAT | |
| SCHEMBL19669976 | 0.84 | HTR2A (0.52) | CA2CA9LMNASMN1; SMN2GAA | |
| SCHEMBL12654500 | 0.84 | CA2 (0.44) | CA2CA9SMN1; SMN2GAATRPV1 | |
| SCHEMBL16776364 | 0.84 | CA2 (0.43) | CA2CA9PLGPLAUPLAT | |
| SCHEMBL19705998 | 0.84 | TRPA1 (0.38) | CA2CA9FYNMAPTADORA2A | |
| SCHEMBL19670371 | 0.83 | NAMPT (0.44) | CA2CA9LMNASMN1; SMN2GAA | |
| SCHEMBL20632523 | 0.83 | ADORA2A (0.37) | CA2CA9SMN1; SMN2FYNADORA2A | |
| SCHEMBL19365508 | 0.83 | FGFR4 (0.42) | CA2CA9LMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |