Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 6/20 | 0.34 |
| ▸ | BRAF | P15056 | 6/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632954 | 0.92 | FYN (0.37) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL20632114 | 0.83 | FYN (0.39) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL17618334 | 0.82 | TRPV1 (0.36) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL19706044 | 0.82 | FYN (0.35) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL16249949 | 0.81 | FYN (0.34) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL19365749 | 0.79 | CA2 (0.42) | RAF1BRAFCA2CA9TRPV1 | |
| Trifluoroacetic Acid SCHEMBL16238443 | 0.79 | TRPV1 (0.34) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL19670249 | 0.79 | CA2 (0.42) | RAF1BRAFCA2CA9RIPK1 | |
| SCHEMBL16776412 | 0.77 | FYN (0.41) | FYNRAF1BRAFCA2CA9 | |
| SCHEMBL17624670 | 0.77 | CA2 (0.39) | RAF1BRAFCA2CA9RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |