Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365749 | 0.93 | CA2 (0.42) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19365537 | 0.90 | CA2 (0.43) | CA2CA9PLGPLAUPLAT | |
| SCHEMBL19365573 | 0.89 | CA2 (0.39) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL17624670 | 0.87 | CA2 (0.39) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19706277 | 0.87 | CA2 (0.39) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19670366 | 0.87 | NAMPT (0.42) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19670123 | 0.86 | TRPA1 (0.37) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19699078 | 0.86 | NAMPT (0.42) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19865035 | 0.85 | CA2 (0.37) | CA2CA9BACE1LMNAFAAH | |
| SCHEMBL19365407 | 0.85 | MEN1 (0.49) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |