Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 4/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670249 | 0.93 | CA2 (0.42) | CA2CA9DHODHRAF1TRPV1 | |
| SCHEMBL19365573 | 0.88 | CA2 (0.39) | CA2CA9RAF1BRAFCHRM4 | |
| SCHEMBL19670123 | 0.88 | TRPA1 (0.37) | CA2CA9CNR1RAF1BRAF | |
| SCHEMBL19365407 | 0.87 | MEN1 (0.49) | TRPV1MEN1POLBKMT2A | |
| SCHEMBL19670366 | 0.86 | NAMPT (0.42) | CA2CA9RAF1BRAFCHRM4 | |
| SCHEMBL17624670 | 0.86 | CA2 (0.39) | CA2CA9RAF1BRAFCHRM4 | |
| SCHEMBL19706277 | 0.86 | CA2 (0.39) | CA2CA9CNR1RAF1BRAF | |
| SCHEMBL19364921 | 0.86 | KIF18A (0.38) | CA2CA9RAF1BRAFCHRM4 | |
| SCHEMBL17623988 | 0.85 | NPC1 (0.37) | CA2CA9RAF1BRAFCHRM4 | |
| SCHEMBL19699078 | 0.85 | NAMPT (0.42) | CA2CA9RAF1BRAFCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |