Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 5/20 | 0.50 |
| ▸ | ADCY8 | P40145 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16250000 | 0.95 | ADCY1 (0.49) | ADCY1ADCY8KDM4EHTTHSD17B10 | |
| SCHEMBL17618853 | 0.87 | ADCY1 (0.42) | ADCY1ADCY8KDM4EHTTLMNA | |
| SCHEMBL17618854 | 0.87 | ADCY1 (0.40) | ADCY1ADCY8KDM4EHTTLMNA | |
| SCHEMBL19365413 | 0.87 | ADCY1 (0.50) | ADCY1ADCY8KDM4EHTTHSD17B10 | |
| SCHEMBL19699081 | 0.87 | IDH2 (0.46) | HTTLMNAIDH2ALDH1A1 | |
| SCHEMBL19706157 | 0.82 | ADCY1 (0.52) | ADCY1ADCY8KDM4EHTTHSD17B10 | |
| SCHEMBL16775953 | 0.82 | TRPV1 (0.44) | KDM4EHTTHSD17B10LMNAL3MBTL1 | |
| SCHEMBL17618348 | 0.82 | IDH2 (0.45) | HTTLMNAIDH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL16238615 | 0.81 | FAAH (0.41) | HTTLMNAIDH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19689798 | 0.81 | LMNA (0.38) | KDM4ELMNAALOX15SRPK1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |