Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624473 | 1.00 | POLB (0.39) | POLBMAP4K4EIF2AK4KMT2ATRPV3 | |
| SCHEMBL19670613 | 0.90 | DGAT2 (0.41) | MAP4K4EIF2AK4TRPV3SCN10ADGAT2 | |
| SCHEMBL20632829 | 0.90 | DGAT2 (0.41) | MAP4K4EIF2AK4TRPV3SCN10ADGAT2 | |
| SCHEMBL17624598 | 0.90 | DGAT2 (0.41) | MAP4K4EIF2AK4TRPV3SCN10ADGAT2 | |
| SCHEMBL17624480 | 0.89 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4TRPV3SCN10A | |
| SCHEMBL19670288 | 0.89 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4TRPV3SCN10A | |
| SCHEMBL16754452 | 0.88 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4KMT2ATRPV3 | |
| SCHEMBL16754325 | 0.88 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4KMT2ATRPV3 | |
| SCHEMBL19670304 | 0.88 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4KMT2ATRPV3 | |
| SCHEMBL19365453 | 0.88 | MAP4K4 (0.41) | POLBMAP4K4EIF2AK4KMT2ATRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |