Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624598 | 1.00 | DGAT2 (0.41) | DGAT2TRPV1MAP4K4TRPV3EIF2AK4 | |
| SCHEMBL19670613 | 1.00 | DGAT2 (0.41) | DGAT2TRPV1MAP4K4TRPV3EIF2AK4 | |
| SCHEMBL19670451 | 0.91 | MAP4K4 (0.41) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL17624401 | 0.91 | MAP4K4 (0.41) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL19670203 | 0.90 | POLB (0.39) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL17624473 | 0.90 | POLB (0.39) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL19670288 | 0.90 | MAP4K4 (0.41) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL17624480 | 0.90 | MAP4K4 (0.41) | DGAT2MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL19670485 | 0.88 | MAP4K4 (0.39) | MAP4K4TRPV3EIF2AK4SCN10AJAK2 | |
| SCHEMBL16754714 | 0.87 | MAP4K4 (0.42) | DGAT2TRPV1MAP4K4TRPV3EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |